If you are asking can you take Benadryl and melatonin, it is important to know that both can make you sleepy. The key question is not whether they can physically be swallowed together, but whether combining them adds more sedation and risk than benefit. Benadryl and melatonin are both easy to buy without a prescription in the United States, which can make the combination seem automatically low-risk. They work very differently, though. Benadryl contains diphenhydramine,…